• Ray WA, Chung CP, Murray KT, Cooper WO, Hall K, Stein CM. Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain. JAMA internal medicine. 2015 Mar 1;175(3). 420-7. PMID: 25599329 [PubMed]. PMCID: PMC4346542. NIHMSID: NIHMS641066.


Growing methadone use in pain management has raised concerns regarding its safety relative to other long-acting opioids. Methadone hydrochloride may increase the risk for lethal respiratory depression related to accidental overdose and life-threatening ventricular arrhythmias.