Blog RSS https://www.vumc.org/gapcancerstudy/ en Investigators Struggle to Understand Causes Behind Growth of Appendix Cancer https://www.vumc.org/gapcancerstudy/our-impact/investigators-struggle-understand-causes-behind-growth-appendix-cancer <span class="field field--name-title field--type-string field--label-hidden">Investigators Struggle to Understand Causes Behind Growth of Appendix Cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 03/16/2023 - 15:04</span> <a href="/gapcancerstudy/blog-post-rss/194" class="feed-icon" title="Subscribe to Investigators Struggle to Understand Causes Behind Growth of Appendix Cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.onclive.com/view/investigators-struggle-to-understand-causes-behind-growth-of-appendix-cancer" target="_blank">https://www.onclive.com/view/investigators-struggle-to-understand-causes-behind-growth-of-appendix-cancer</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>“My team conducted a few studies, particularly one that wanted to look at the burden of appendix cancers in young adults,” she said. “And what we strikingly found there was that, in contrast to the fact that about 1 in every 5 colorectal cancer patients is diagnosed before the age of 50, we found that 1 in every 3 [30.8%] appendix cancer patients are diagnosed before age 50.4. Noting this really disproportionate burden in younger patients really spurred a lot of the subsequent work that my lab has done and continues to do."</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Thu, 16 Mar 2023 20:04:56 +0000 kellesr2 194 at https://www.vumc.org/gapcancerstudy Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer https://www.vumc.org/gapcancerstudy/our-impact/inherited-cancer-susceptibility-gene-sequence-variations-among-patients-appendix-cancer <span class="field field--name-title field--type-string field--label-hidden">Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:52</span> <a href="/gapcancerstudy/blog-post-rss/193" class="feed-icon" title="Subscribe to Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://jamanetwork.com/journals/jamaoncology/fullarticle/2798729" target="_blank">https://jamanetwork.com/journals/jamaoncology/fullarticle/2798729</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Dr. Holowatyj recently led a study that discovered the first genetic link to appendix cancer. "In this cohort study of 131 patients with appendix cancer who underwent clinical multigene panel testing, 11.5% harbored a pathogenic sequence variation. Among 74 patients with appendix cancer as the first and only primary tumor, a similar proportion (10.8%) carried a pathogenic sequence variation." The findings suggest that appendiceal cancer may be a previously underrecognized indication for hereditary cancer genetic testing (or a hereditary cancer syndrome) and that genetic evaluation should be considered for all patients with appendix cancer.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:52:03 +0000 kellesr2 193 at https://www.vumc.org/gapcancerstudy Cancer of the Appendix: Very Rare, But Genes May Play Role https://www.vumc.org/gapcancerstudy/our-impact/cancer-appendix-very-rare-genes-may-play-role-0 <span class="field field--name-title field--type-string field--label-hidden">Cancer of the Appendix: Very Rare, But Genes May Play Role</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:50</span> <a href="/gapcancerstudy/blog-post-rss/192" class="feed-icon" title="Subscribe to Cancer of the Appendix: Very Rare, But Genes May Play Role"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.usnews.com/news/health-news/articles/2022-11-14/cancer-of-the-appendix-very-rare-but-genes-may-play-role" target="_blank">https://www.usnews.com/news/health-news/articles/2022-11-14/cancer-of-the-appendix-very-rare-but-genes-may-play-role</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>"While there is still much to learn from our discovery, we have found the tip of an iceberg -- potentially a really big iceberg," Holowatyj said in a center news release. Historically, experts have not thought this cancer, which affects about one or two people in 1 million annually, was hereditary. The fact that it's rare has made it even harder to understand and study.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:50:47 +0000 kellesr2 192 at https://www.vumc.org/gapcancerstudy Genetic variant may be linked to cancer of the appendix https://www.vumc.org/gapcancerstudy/our-impact/genetic-variant-may-be-linked-cancer-appendix-0 <span class="field field--name-title field--type-string field--label-hidden">Genetic variant may be linked to cancer of the appendix</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:49</span> <a href="/gapcancerstudy/blog-post-rss/191" class="feed-icon" title="Subscribe to Genetic variant may be linked to cancer of the appendix"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.msn.com/en-us/health/medical/genetic-variant-may-be-linked-to-cancer-of-the-appendix/ar-AA1469jm" target="_blank">https://www.msn.com/en-us/health/medical/genetic-variant-may-be-linked-to-cancer-of-the-appendix/ar-AA1469jm</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Researchers found that 11.5% of the patients had at least one inherited genetic variant in a cancer susceptibility gene. In the patients whose appendix cancer was the first and only primary tumor, researchers noted a similar prevalence, about 10.8%. This further links the disease to a familial component.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:49:04 +0000 kellesr2 191 at https://www.vumc.org/gapcancerstudy Study shows inherited risk factors for appendiceal cancer https://www.vumc.org/gapcancerstudy/our-impact/study-shows-inherited-risk-factors-appendiceal-cancer <span class="field field--name-title field--type-string field--label-hidden">Study shows inherited risk factors for appendiceal cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:48</span> <a href="/gapcancerstudy/blog-post-rss/190" class="feed-icon" title="Subscribe to Study shows inherited risk factors for appendiceal cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Appendiceal cancer affects about one or two people per million annually. Historically it has been thought that appendiceal cancer is not hereditary, but its rarity has presented challenges for understanding the characteristics of the disease and developing therapies. A research team led by Andreana Holowatyj, PhD, MSCI, assistant professor of Medicine and Cancer Biology at Vanderbilt University Medical Center, analyzed multigene panel testing data from a nationwide clinical testing laboratory in the U.S. for a total of 131 patients with appendiceal cancer. </p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:48:02 +0000 kellesr2 190 at https://www.vumc.org/gapcancerstudy Genetic Testing “Should Be Considered” for All Patients With Appendix Cancer https://www.vumc.org/gapcancerstudy/our-impact/genetic-testing-should-be-considered-all-patients-appendix-cancer-0 <span class="field field--name-title field--type-string field--label-hidden">Genetic Testing “Should Be Considered” for All Patients With Appendix Cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:46</span> <a href="/gapcancerstudy/blog-post-rss/189" class="feed-icon" title="Subscribe to Genetic Testing “Should Be Considered” for All Patients With Appendix Cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.cancertherapyadvisor.com/home/cancer-topics/gastrointestinal-cancers/genetic-testing-should-be-considered-for-all-patients-with-appendix-cancer/" target="_blank">https://www.cancertherapyadvisor.com/home/cancer-topics/gastrointestinal-cancers/genetic-testing-should-be-considered-for-all-patients-with-appendix-cancer/</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><meta charset="UTF-8" />“Given the high frequency and broad spectrum of germline gene sequence variations, these data suggest that genetic evaluation might be warranted for all patients diagnosed with this rare malignant tumor,” the researchers wrote. “A systemic sequencing effort for all patients with AC [appendix cancer] may also identify cancer vulnerabilities to exploit for therapeutic development in a cancer type for which clinical trials are limited.”</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:46:35 +0000 kellesr2 189 at https://www.vumc.org/gapcancerstudy Number of Appendiceal Cancer Patients Harbor Cancer Predisposition Gene Variants https://www.vumc.org/gapcancerstudy/our-impact/number-appendiceal-cancer-patients-harbor-cancer-predisposition-gene-variants-0 <span class="field field--name-title field--type-string field--label-hidden">Number of Appendiceal Cancer Patients Harbor Cancer Predisposition Gene Variants</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:45</span> <a href="/gapcancerstudy/blog-post-rss/188" class="feed-icon" title="Subscribe to Number of Appendiceal Cancer Patients Harbor Cancer Predisposition Gene Variants"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.genomeweb.com/scan/number-appendiceal-cancer-patients-harbor-cancer-predisposition-gene-variants#.Y4TJcS-B3fJ" target="_blank">https://www.genomeweb.com/scan/number-appendiceal-cancer-patients-harbor-cancer-predisposition-gene-variants#.Y4TJcS-B3fJ</a></div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:45:15 +0000 kellesr2 188 at https://www.vumc.org/gapcancerstudy Study Shows Inherited Risk Factors For Appendiceal Cancer https://www.vumc.org/gapcancerstudy/our-impact/study-shows-inherited-risk-factors-appendiceal-cancer-1 <span class="field field--name-title field--type-string field--label-hidden">Study Shows Inherited Risk Factors For Appendiceal Cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:42</span> <a href="/gapcancerstudy/blog-post-rss/187" class="feed-icon" title="Subscribe to Study Shows Inherited Risk Factors For Appendiceal Cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://health-reporter.news/study-shows-inherited-risk-factors-for-appendiceal-cancer/" target="_blank">https://health-reporter.news/study-shows-inherited-risk-factors-for-appendiceal-cancer/</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><meta charset="UTF-8" />One of every 10 patients with appendiceal cancer carries a germline genetic variant associated with cancer predisposition, according to a study in JAMA Oncology that is the first to show inherited risk factors for this rare cancer.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:42:43 +0000 kellesr2 187 at https://www.vumc.org/gapcancerstudy Study finds inherited link to appendix cancer https://www.vumc.org/gapcancerstudy/our-impact/study-finds-inherited-link-appendix-cancer <span class="field field--name-title field--type-string field--label-hidden">Study finds inherited link to appendix cancer</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:40</span> <a href="/gapcancerstudy/blog-post-rss/186" class="feed-icon" title="Subscribe to Study finds inherited link to appendix cancer"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://news.vumc.org/2022/11/11/study-finds-inherited-link-to-appendix-cancer/" target="_blank">https://news.vumc.org/2022/11/11/study-finds-inherited-link-to-appendix-cancer/</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Although appendiceal cancer is rare, it is becoming more common for reasons that are not known. Last year, Holowatyj and colleagues conducted the first study of appendiceal cancer patterns and survival among patients younger than 50 (early-onset disease) in the U.S. They found poorer disease outcomes among non-Hispanic Blacks compared to non-Hispanic whites, and among men compared with women.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:40:33 +0000 kellesr2 186 at https://www.vumc.org/gapcancerstudy Genetic variant may be linked to cancer of the appendix https://www.vumc.org/gapcancerstudy/our-impact/genetic-variant-may-be-linked-cancer-appendix-2 <span class="field field--name-title field--type-string field--label-hidden">Genetic variant may be linked to cancer of the appendix</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:39</span> <a href="/gapcancerstudy/blog-post-rss/185" class="feed-icon" title="Subscribe to Genetic variant may be linked to cancer of the appendix"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.upi.com/Health_News/2022/11/14/cancer-appendix-genes/2701668437640/" target="_blank">https://www.upi.com/Health_News/2022/11/14/cancer-appendix-genes/2701668437640/</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>In the patients whose appendix cancer was the first and only primary tumor, researchers noted a similar prevalence, about 10.8%. This further links the disease to a familial component.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:39:03 +0000 kellesr2 185 at https://www.vumc.org/gapcancerstudy The Buffalo News https://www.vumc.org/gapcancerstudy/our-impact/buffalo-news-0 <span class="field field--name-title field--type-string field--label-hidden">The Buffalo News</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:37</span> <a href="/gapcancerstudy/blog-post-rss/184" class="feed-icon" title="Subscribe to The Buffalo News"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://buffalonews.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_af95f4e2-b3e5-5c47-b518-a46fe2426de5.html" target="_blank">https://buffalonews.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_af95f4e2-b3e5-5c47-b518-a46fe2426de5.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Andreana N. Holowatyj, Ph.D., from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues examined the prevalence and spectrum of inherited cancer susceptibility gene sequence variations in a cohort of patients with AC who underwent germline genetic testing of 14 cancer susceptibility genes. The cohort included 131 patients with AC.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:37:10 +0000 kellesr2 184 at https://www.vumc.org/gapcancerstudy Physicians Weekly https://www.vumc.org/gapcancerstudy/our-impact/physicians-weekly <span class="field field--name-title field--type-string field--label-hidden">Physicians Weekly </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:36</span> <a href="/gapcancerstudy/blog-post-rss/183" class="feed-icon" title="Subscribe to Physicians Weekly "> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.physiciansweekly.com/oncogenic-variants-identified-in-10-percent-with-appendix-cancer" target="_blank">https://www.physiciansweekly.com/oncogenic-variants-identified-in-10-percent-with-appendix-cancer</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in <em>JAMA Oncology</em>.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:36:08 +0000 kellesr2 183 at https://www.vumc.org/gapcancerstudy Drugs.com https://www.vumc.org/gapcancerstudy/our-impact/drugscom-0 <span class="field field--name-title field--type-string field--label-hidden">Drugs.com</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:33</span> <a href="/gapcancerstudy/blog-post-rss/182" class="feed-icon" title="Subscribe to Drugs.com"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.drugs.com/news/oncogenic-variants-identified-10-percent-appendix-cancer-109136.html" target="_blank">https://www.drugs.com/news/oncogenic-variants-identified-10-percent-appendix-cancer-109136.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>"These findings support the consideration of genetic testing for all patients with appendix cancer irrespective of age or family history," the authors write. "The consideration of a more systemic sequencing effort for all patients with appendiceal cancer may provide important evidence toward tailoring genes selected for germline genetic testing for appendiceal cancer across specific patient groups."</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:33:43 +0000 kellesr2 182 at https://www.vumc.org/gapcancerstudy The Lincoln Journal Star https://www.vumc.org/gapcancerstudy/our-impact/lincoln-journal-star-0 <span class="field field--name-title field--type-string field--label-hidden">The Lincoln Journal Star</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:32</span> <a href="/gapcancerstudy/blog-post-rss/181" class="feed-icon" title="Subscribe to The Lincoln Journal Star"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://journalstar.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_6c467c7f-269a-535a-a43a-5959c59dd2e9.html" target="_blank">https://journalstar.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_6c467c7f-269a-535a-a43a-5959c59dd2e9.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Six patients (4.6 percent) had a deleterious sequence variation in <em>MUTYH</em> (five monoallelic and one biallelic). Four patients (3.1 percent) had Lynch syndrome and had a sequence variation in the <em>MLH1</em> gene; three were aged 50 years or older at AC diagnosis. Deleterious sequence variations in other cancer predisposition genes (<em>APC</em>, <em>CHEK2</em>, <em>SMAD4</em>, and <em>TP53</em>) were seen for five patients (3.8 percent).</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:32:35 +0000 kellesr2 181 at https://www.vumc.org/gapcancerstudy KOAMNewsNow.com https://www.vumc.org/gapcancerstudy/our-impact/koamnewsnowcom <span class="field field--name-title field--type-string field--label-hidden">KOAMNewsNow.com</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:31</span> <a href="/gapcancerstudy/blog-post-rss/180" class="feed-icon" title="Subscribe to KOAMNewsNow.com"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.koamnewsnow.com/i/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/" target="_blank">https://www.koamnewsnow.com/i/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The researchers identified 16 deleterious sequence variations in 15 patients (11.5 percent). When limited to the 74 patients with AC as the first and only primary tumor, eight patients (10.8 percent) had at least one deleterious sequence variation in a cancer susceptibility gene. </p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:31:11 +0000 kellesr2 180 at https://www.vumc.org/gapcancerstudy The Columbus Telegram https://www.vumc.org/gapcancerstudy/our-impact/columbus-telegram-0 <span class="field field--name-title field--type-string field--label-hidden">The Columbus Telegram</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:29</span> <a href="/gapcancerstudy/blog-post-rss/179" class="feed-icon" title="Subscribe to The Columbus Telegram"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://columbustelegram.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_f4cfccad-2dbf-5933-a6f5-bf69c93d6715.html" target="_blank">https://columbustelegram.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_f4cfccad-2dbf-5933-a6f5-bf69c93d6715.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Andreana N. Holowatyj, Ph.D., from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues examined the prevalence and spectrum of inherited cancer susceptibility gene sequence variations in a cohort of patients with AC who underwent germline genetic testing of 14 cancer susceptibility genes. The cohort included 131 patients with AC.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:29:52 +0000 kellesr2 179 at https://www.vumc.org/gapcancerstudy Arizona Daily Star https://www.vumc.org/gapcancerstudy/our-impact/arizona-daily-star-0 <span class="field field--name-title field--type-string field--label-hidden">Arizona Daily Star</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:28</span> <a href="/gapcancerstudy/blog-post-rss/178" class="feed-icon" title="Subscribe to Arizona Daily Star"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://tucson.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_a0bb8041-dabe-50c6-a2e0-764bb95679e0.html" target="_blank">https://tucson.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_a0bb8041-dabe-50c6-a2e0-764bb95679e0.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in <em>JAMA Oncology</em>.</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:28:42 +0000 kellesr2 178 at https://www.vumc.org/gapcancerstudy WFMZ-TV https://www.vumc.org/gapcancerstudy/our-impact/wfmz-tv <span class="field field--name-title field--type-string field--label-hidden">WFMZ-TV</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:27</span> <a href="/gapcancerstudy/blog-post-rss/177" class="feed-icon" title="Subscribe to WFMZ-TV"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.wfmz.com/health/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_1bc491d5-b64b-5145-aa61-d3ecef01d5e1.html" target="_blank">https://www.wfmz.com/health/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_1bc491d5-b64b-5145-aa61-d3ecef01d5e1.html</a></div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:27:05 +0000 kellesr2 177 at https://www.vumc.org/gapcancerstudy St. Louis Post Dispatch https://www.vumc.org/gapcancerstudy/our-impact/st-louis-post-dispatch-0 <span class="field field--name-title field--type-string field--label-hidden">St. Louis Post Dispatch</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:25</span> <a href="/gapcancerstudy/blog-post-rss/176" class="feed-icon" title="Subscribe to St. Louis Post Dispatch"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://www.stltoday.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_16976502-fa0d-59d1-927d-bea1d9dd5204.html" target="_blank">https://www.stltoday.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_16976502-fa0d-59d1-927d-bea1d9dd5204.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>"These findings support the consideration of genetic testing for all patients with appendix cancer irrespective of age or family history," the authors write. "The consideration of a more systemic sequencing effort for all patients with appendiceal cancer may provide important evidence toward tailoring genes selected for germline genetic testing for appendiceal cancer across specific patient groups."</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:25:40 +0000 kellesr2 176 at https://www.vumc.org/gapcancerstudy The Sentinel https://www.vumc.org/gapcancerstudy/our-impact/sentinel-0 <span class="field field--name-title field--type-string field--label-hidden">The Sentinel</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/gapcancerstudy/users/kellesr2" typeof="schema:Person" property="schema:name" datatype="">kellesr2</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/28/2022 - 08:24</span> <a href="/gapcancerstudy/blog-post-rss/175" class="feed-icon" title="Subscribe to The Sentinel"> RSS: <i class="fa fa-rss-square"></i> </a> <div class="field field--name-field-barista-posts-external-url field--type-link field--label-hidden field__item"><a href="https://cumberlink.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_59aa7b14-b1b9-5c97-9594-dce7a5ce282f.html" target="_blank">https://cumberlink.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_59aa7b14-b1b9-5c97-9594-dce7a5ce282f.html</a></div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Six patients (4.6 percent) had a deleterious sequence variation in <em>MUTYH</em> (five monoallelic and one biallelic). Four patients (3.1 percent) had Lynch syndrome and had a sequence variation in the <em>MLH1</em> gene; three were aged 50 years or older at AC diagnosis. Deleterious sequence variations in other cancer predisposition genes (<em>APC</em>, <em>CHEK2</em>, <em>SMAD4</em>, and <em>TP53</em>) were seen for five patients (3.8 percent).</p> </div> <div class="field field--name-field-lockdown-auth field--type-string field--label-above"> <div class="field__label">Lockdown Auth</div> <div class="field__item">1</div> </div> Mon, 28 Nov 2022 14:24:40 +0000 kellesr2 175 at https://www.vumc.org/gapcancerstudy