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Medical Mystery: Why Are So Many More Young People Getting Appendix Cancer?

holowaa — Fri, 01 Sep 2023 19:21:58 +0000

Medical Mystery: Why Are So Many More Young People Getting Appendix Cancer? holowaa Fri, 09/01/2023 - 14:21 RSS:

https://www.survivornet.com/articles/medical-mystery-why-are-so-many-more-young-people-getting-appendix-cancer/

“That study really is the tip of an iceberg, and potentially quite a big iceberg, in that it’s spurred us opening a clinical study both at Vanderbilt and nationwide called the Genetics of Appendix Cancer study or GAP [NCT05734430], where any individual diagnosed with appendix cancer in the United States is eligible to participate and will help us learn more about this genetic predisposition and these genetic factors overall,” Dr. Holowatyj noted.

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Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer

kopcol — Mon, 26 Jun 2023 14:32:34 +0000

Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer kopcol Mon, 06/26/2023 - 09:32 RSS:

https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.3322/caac.21806

"This article highlights the critical clinical components of the now published version 9 AJCC staging system for appendix cancer, which (1) justified the separation of three different histologies (non-mucinous, mucinous, signet-ring cell) in terms of prognostic variance, (2) demonstrated the clinical implications and challenges in staging heterogeneous and rare tumors, and (3) emphasized the influence of data limitations on survival analysis for low-grade appendiceal mucinous neoplasms."

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Investigators Struggle to Understand Causes Behind Growth of Appendix Cancer

kellesr2 — Thu, 16 Mar 2023 20:04:56 +0000

Investigators Struggle to Understand Causes Behind Growth of Appendix Cancer kellesr2 Thu, 03/16/2023 - 15:04 RSS:

https://www.onclive.com/view/investigators-struggle-to-understand-causes-behind-growth-of-appendix-cancer

“My team conducted a few studies, particularly one that wanted to look at the burden of appendix cancers in young adults,” [Dr. Holowatyj] said. “And what we strikingly found there was that, in contrast to the fact that about 1 in every 5 colorectal cancer patients is diagnosed before the age of 50, we found that 1 in every 3 [30.8%] appendix cancer patients are diagnosed before age 50. Noting this really disproportionate burden in younger patients really spurred a lot of the subsequent work that my lab has done and continues to do."

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Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer

kellesr2 — Mon, 28 Nov 2022 14:52:03 +0000

Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer kellesr2 Mon, 11/28/2022 - 08:52 RSS:

https://jamanetwork.com/journals/jamaoncology/fullarticle/2798729

Dr. Holowatyj recently led a study that discovered the first genetic link to appendix cancer. "In this cohort study of 131 patients with appendix cancer who underwent clinical multigene panel testing, 11.5% harbored a pathogenic sequence variation. Among 74 patients with appendix cancer as the first and only primary tumor, a similar proportion (10.8%) carried a pathogenic sequence variation." The findings suggest that appendiceal cancer may be a previously underrecognized indication for hereditary cancer genetic testing (or a hereditary cancer syndrome) and that genetic evaluation should be considered for all patients with appendix cancer.

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Cancer of the Appendix: Very Rare, But Genes May Play Role

kellesr2 — Mon, 28 Nov 2022 14:50:47 +0000

Cancer of the Appendix: Very Rare, But Genes May Play Role kellesr2 Mon, 11/28/2022 - 08:50 RSS:

https://www.usnews.com/news/health-news/articles/2022-11-14/cancer-of-the-appendix-very-rare-but-genes-may-play-role

"While there is still much to learn from our discovery, we have found the tip of an iceberg -- potentially a really big iceberg," Holowatyj said in a center news release. Historically, experts have not thought this cancer, which affects about one or two people in 1 million annually, was hereditary. The fact that it's rare has made it even harder to understand and study.

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Genetic variant may be linked to cancer of the appendix

kellesr2 — Mon, 28 Nov 2022 14:49:04 +0000

Genetic variant may be linked to cancer of the appendix kellesr2 Mon, 11/28/2022 - 08:49 RSS:

https://www.msn.com/en-us/health/medical/genetic-variant-may-be-linked-to-cancer-of-the-appendix/ar-AA1469jm

Researchers found that 11.5% of the patients had at least one inherited genetic variant in a cancer susceptibility gene. In the patients whose appendix cancer was the first and only primary tumor, researchers noted a similar prevalence, about 10.8%. This further links the disease to a familial component.

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Study shows inherited risk factors for appendiceal cancer

kellesr2 — Mon, 28 Nov 2022 14:48:02 +0000

Study shows inherited risk factors for appendiceal cancer kellesr2 Mon, 11/28/2022 - 08:48 RSS:

Appendiceal cancer affects about one or two people per million annually. Historically it has been thought that appendiceal cancer is not hereditary, but its rarity has presented challenges for understanding the characteristics of the disease and developing therapies. A research team led by Andreana Holowatyj, PhD, MSCI, assistant professor of Medicine and Cancer Biology at Vanderbilt University Medical Center, analyzed multigene panel testing data from a nationwide clinical testing laboratory in the U.S. for a total of 131 patients with appendiceal cancer.

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Genetic Testing “Should Be Considered” for All Patients With Appendix Cancer

kellesr2 — Mon, 28 Nov 2022 14:46:35 +0000

Genetic Testing “Should Be Considered” for All Patients With Appendix Cancer kellesr2 Mon, 11/28/2022 - 08:46 RSS:

https://www.cancertherapyadvisor.com/home/cancer-topics/gastrointestinal-cancers/genetic-testing-should-be-considered-for-all-patients-with-appendix-cancer/

“Given the high frequency and broad spectrum of germline gene sequence variations, these data suggest that genetic evaluation might be warranted for all patients diagnosed with this rare malignant tumor,” the researchers wrote. “A systemic sequencing effort for all patients with AC [appendix cancer] may also identify cancer vulnerabilities to exploit for therapeutic development in a cancer type for which clinical trials are limited.”

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Number of Appendiceal Cancer Patients Harbor Cancer Predisposition Gene Variants

kellesr2 — Mon, 28 Nov 2022 14:45:15 +0000

Number of Appendiceal Cancer Patients Harbor Cancer Predisposition Gene Variants kellesr2 Mon, 11/28/2022 - 08:45 RSS:

https://www.genomeweb.com/scan/number-appendiceal-cancer-patients-harbor-cancer-predisposition-gene-variants#.Y4TJcS-B3fJ

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Study Shows Inherited Risk Factors For Appendiceal Cancer

kellesr2 — Mon, 28 Nov 2022 14:42:43 +0000

Study Shows Inherited Risk Factors For Appendiceal Cancer kellesr2 Mon, 11/28/2022 - 08:42 RSS:

https://health-reporter.news/study-shows-inherited-risk-factors-for-appendiceal-cancer/

One of every 10 patients with appendiceal cancer carries a germline genetic variant associated with cancer predisposition, according to a study in JAMA Oncology that is the first to show inherited risk factors for this rare cancer.

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Study finds inherited link to appendix cancer

kellesr2 — Mon, 28 Nov 2022 14:40:33 +0000

Study finds inherited link to appendix cancer kellesr2 Mon, 11/28/2022 - 08:40 RSS:

https://news.vumc.org/2022/11/11/study-finds-inherited-link-to-appendix-cancer/

Although appendiceal cancer is rare, it is becoming more common for reasons that are not known. Last year, Holowatyj and colleagues conducted the first study of appendiceal cancer patterns and survival among patients younger than 50 (early-onset disease) in the U.S. They found poorer disease outcomes among non-Hispanic Blacks compared to non-Hispanic whites, and among men compared with women.

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Genetic variant may be linked to cancer of the appendix

kellesr2 — Mon, 28 Nov 2022 14:39:03 +0000

Genetic variant may be linked to cancer of the appendix kellesr2 Mon, 11/28/2022 - 08:39 RSS:

https://www.upi.com/Health_News/2022/11/14/cancer-appendix-genes/2701668437640/

In the patients whose appendix cancer was the first and only primary tumor, researchers noted a similar prevalence, about 10.8%. This further links the disease to a familial component.

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The Buffalo News

kellesr2 — Mon, 28 Nov 2022 14:37:10 +0000

The Buffalo News kellesr2 Mon, 11/28/2022 - 08:37 RSS:

https://buffalonews.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_af95f4e2-b3e5-5c47-b518-a46fe2426de5.html

Andreana N. Holowatyj, Ph.D., from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues examined the prevalence and spectrum of inherited cancer susceptibility gene sequence variations in a cohort of patients with AC who underwent germline genetic testing of 14 cancer susceptibility genes. The cohort included 131 patients with AC.

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Physicians Weekly

kellesr2 — Mon, 28 Nov 2022 14:36:08 +0000

Physicians Weekly kellesr2 Mon, 11/28/2022 - 08:36 RSS:

https://www.physiciansweekly.com/oncogenic-variants-identified-in-10-percent-with-appendix-cancer

About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with cancer susceptibility, according to a study published online Nov. 11 in JAMA Oncology.

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Drugs.com

kellesr2 — Mon, 28 Nov 2022 14:33:43 +0000

Drugs.com kellesr2 Mon, 11/28/2022 - 08:33 RSS:

https://www.drugs.com/news/oncogenic-variants-identified-10-percent-appendix-cancer-109136.html

"These findings support the consideration of genetic testing for all patients with appendix cancer irrespective of age or family history," the authors write. "The consideration of a more systemic sequencing effort for all patients with appendiceal cancer may provide important evidence toward tailoring genes selected for germline genetic testing for appendiceal cancer across specific patient groups."

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The Lincoln Journal Star

kellesr2 — Mon, 28 Nov 2022 14:32:35 +0000

The Lincoln Journal Star kellesr2 Mon, 11/28/2022 - 08:32 RSS:

https://journalstar.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_6c467c7f-269a-535a-a43a-5959c59dd2e9.html

Six patients (4.6 percent) had a deleterious sequence variation in MUTYH (five monoallelic and one biallelic). Four patients (3.1 percent) had Lynch syndrome and had a sequence variation in the MLH1 gene; three were aged 50 years or older at AC diagnosis. Deleterious sequence variations in other cancer predisposition genes (APC, CHEK2, SMAD4, and TP53) were seen for five patients (3.8 percent).

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KOAMNewsNow.com

kellesr2 — Mon, 28 Nov 2022 14:31:11 +0000

KOAMNewsNow.com kellesr2 Mon, 11/28/2022 - 08:31 RSS:

https://www.koamnewsnow.com/i/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/

The researchers identified 16 deleterious sequence variations in 15 patients (11.5 percent). When limited to the 74 patients with AC as the first and only primary tumor, eight patients (10.8 percent) had at least one deleterious sequence variation in a cancer susceptibility gene.

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The Columbus Telegram

kellesr2 — Mon, 28 Nov 2022 14:29:52 +0000

The Columbus Telegram kellesr2 Mon, 11/28/2022 - 08:29 RSS:

https://columbustelegram.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_f4cfccad-2dbf-5933-a6f5-bf69c93d6715.html

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Arizona Daily Star

kellesr2 — Mon, 28 Nov 2022 14:28:42 +0000

Arizona Daily Star kellesr2 Mon, 11/28/2022 - 08:28 RSS:

https://tucson.com/lifestyles/health-med-fit/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_a0bb8041-dabe-50c6-a2e0-764bb95679e0.html

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WFMZ-TV

kellesr2 — Mon, 28 Nov 2022 14:27:05 +0000

WFMZ-TV kellesr2 Mon, 11/28/2022 - 08:27 RSS:

https://www.wfmz.com/health/oncogenic-variants-identified-in-10-percent-with-appendix-cancer/article_1bc491d5-b64b-5145-aa61-d3ecef01d5e1.html

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