Brissova and colleagues sought a system that would enable them to genetically manipulate specific cells within islets and analyze the results
New R01's awarded to Dr. Ray Blind
Congrats to Dr. Blind on his two recently funded R01 awards on gene expression and structural biology.
Pseudoislet system expected to advance pancreas and diabetes research
Marcela Brissova, PhD, and MD/PhD student John “Jack” Walker are part of the research team that developed a pseudoislet system for integrated studies of human islet function. (photo by Donn Jones)
Keeping beta cells “fit”
Guoqiang Gu, PhD, and colleagues have assessed the roles of Sin3a/b in the embryonic development and postnatal function of pancreatic insulin-secreting beta cells.
Decreased pancreatic acinar cell number in type 1 diabetes
Congratulations to Jordan Wright from the Powers lab on the publication of his work on T1D featured in the "Up front" section of Diabetologia. The cover of the July issue also features a graphic from his research. The article is available to read from Springer using the link below.
Pancreatic islet cells distinct in mice and humans
Researchers in the lab of Roland Stein (Molecular Physiology & Biophysics), along with collaborators at UCSF, NC State, and UPenn, have shown distinct changes in human pancreatic islet cells throughout the course of life and the progression of type 2 diabetes. They also discovered distinct phenotypes in human islet cells compared to a mouse model.
Post-transplant diabetes may be reversible
Post-transplantation diabetes mellitus (PTDM), a common complication of immunosuppressive drugs that are given to prevent transplant rejection, may be reversible and at least partially preventable, researchers at Vanderbilt University Medical Center report.
Dr. Maureen Gannon featured on News Channel 4 segment "4 Your Community"
Genetic screen in worms reveals critical step in insulin synthesis
Patrick Hu, MD, PhD, identified a previously unknown step in insulin synthesis, providing new clues to diabetes pathogenesis.
Diabetes drug study explores cardiovascular risks for patients with kidney disease
Over the years there has been uncertainty over which drugs are best for patients with Type 2 diabetes and one of its common complications, kidney disease. An observational study using medical record information from nearly 50,000 U.S. military veterans sheds new light on this issue.
Discovery may point to better treatments for Type 1 diabetes
Researchers at Vanderbilt University Medical Center led by an assistant professor of Pediatrics have made a paradigm-shifting discovery that could lead to new treatments, better health and longer life for patients with Type 1 diabetes.