Study expands insight on shrinking pancreas in type 1 diabetes

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"Researchers with the Vanderbilt Diabetes Research and Training Center (DRTC) have discovered a progressive decline in pancreas volume over a one-year period in children and adolescents with newly diagnosed Type 1 diabetes."

"In the study, Vanderbilt investigators measured pancreas size in more than 50 children and adolescents with newly diagnosed Type 1 diabetes and compared this measure to pancreas size in age-matched individuals without Type 1 diabetes. Measurements were obtained by non-contrast magnetic resonance imaging (MRI) scans taken at the Vanderbilt University Institute of Imaging Science (VUIIS) approximately six months apart."

"Using the MRI-derived information, the investigators calculated the pancreas volume and found that smaller pancreas volume was evident within 100 days of diagnosis of Type 1 diabetes, and pancreas volume continued to decline over the first year after diabetes diagnosis. Individuals with Type 1 diabetes had an average pancreas volume nearly 40% less than those without Type 1 diabetes."

"Other investigators included former Vanderbilt University faculty member Jack Virostko, PhD, now at the Dell Medical School Department of Diagnostic Medicine at the University of Texas at Austin; Daniel Moore, MD, PhD, assistant professor of Pediatrics and an investigator in the Vanderbilt TrialNet Center; Melissa Hilmes, MD, assistant professor of Radiology; and DRTC Director Alvin C. Powers, MD. Hilmes interpreted the more than 300 MRI scans conducted during the study."

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Study as published in Diabetes Care

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset