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Choi, E., Hendley, A. M., Bailey, J. M., Leach, S. D., and Goldenring, J. R. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology 150, 2016; 918-930 e913 PMC4808451


Quesada-Gemez C, Lepez-Ureea D, Chumbler N, Kroh HK, Castro-Peea C, Rodreguez C, Orozco-Aguilar J, Gonzelez-Camacho S, Rucavado A, Guzmen-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun. 2016 Jan 11;84(3):856-65. PMCID: PMC4771349.


Schafer JC, McRae RE, Manning EH, Lapierre LA, Goldenring JR. Rab11-FIP1A regulates early trafficking into the recycling endosomes. Exp Cell Res. 2016 Jan 15;340(2):259-73. PubMed PMID: 26790954; NIHMSID: NIHMS752860; PubMed Central PMCID: PMC4744548.


Varga MG Shaffer CL Sierra JC Suarez G Piazuelo MB Whitaker ME Romero-Gallo J Krishna US Delgado A Gomez MA Good JA Almqvist F Skaar EP Correa P Wilson KT Hadjifrangiskou M Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene. 2016. In press. NIHMSID: 775216.


Weis, G. V., Knowles, B. C., Choi, E., Goldstein, A. E., Williams, J. A., Manning, E. H., Roland, J. T., Lapierre, L. A., and Goldenring, J. R. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cellular and Molecular Gastroenterology and Hepatology, 2016; 2:131-157. PMC4806369.


Yu HH, Dohn MR, Markham NO, Coffey RJ, Reynolds AB. p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. J Cell Sci. 2016 Jan 1;129(1):80-94. PubMed PMID: 26585313; PubMed Central PMCID: PMC4732297.


An H, Stoops SL, Deane NG, Zhu J, Zi J, Weaver C, Waterson AG, Zijlstra A, Lindsley CW, Beauchamp RD. Small molecule/ML327 mediated transcriptional de-repression of Ecadherin and inhibition of epithelial-to-mesenchymal transition. Oncotarget. 2015 Sep 8;6(26):22934-48. PubMed PMID: 26082441; PubMed Central PMCID: PMC4673210.


Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. Selenoprotein P influences colitis induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest. 2015 Jul 1;125(7):2646-60. PubMed PMID: 26053663; PubMed Central PMCID: PMC4563672.


Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI (2015) Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget, 2015; 6:1531-43. PMCID: PMC4359312.


Bolus, W. R., Gutierrez, D. A., Kennedy, A. J., Anderson-Baucum, E. K., and Hasty, A. H. CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. Journal of Leukocyte Biology, 2015; 98, 467-477 PMC4763864


Gaddy JA, Radin JN, Cullen TW, Chazin WJ, Skaar EP, Trent MS, Algood HM. Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation. MBio, 2015 Dec 8;6(6):e01349-15. PubMed PMID: 26646009; PubMed Central PMCID: PMC4669380.


Grega-Larson NE, Crawley SW, Erwin AL, Tyska MJ. Cordon bleu promotes the assembly of brush border microvilli. Mol Biol Cell. 2015 Nov 1;26(21):3803-15. PubMed PMID: 26354418; PubMed Central PMCID: PMC4626065.


Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Mol Metab. 2015 Oct;4(10):665-77. PubMed PMID: 26779432; PubMed Central PMCID: PMC4588436.


Kondo J, Powell AE, Wang Y, Musser MA, Southard-Smith EM, Franklin JL, Coffey RJ. LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology. 2015 Aug;149(2):407-19.e8. PubMed PMID: 25921371; NIHMSID: NIHMS684852; PubMed Central PMCID: PMC4527342.


Koumangoye RB, Andl T, Taubenslag KJ, Zilberman ST, Taylor CJ, Loomans HA, Andl CD, SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. Mol Cancer, 2015; 14:24. [Epub ahead of print] PMCID: PMC4374188.


Musser, M. A., Correa, H., and Southard-Smith, E. M. Enteric neuron imbalance and proximal dysmotility in ganglionated intestine of the Hirschsprung mouse model. Cellular and Molecular Gastroenterology and Hepatology, 2015; 1, 87-101 PMC4380251


Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am J Physiol Gastrointest Liver Physiol, 2015; 308(6):G562-71. PMCID: PMC4360050.


Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR. Hepatic TLR4 signaling in obese NAFLD. Am J Physiol Gastrointest Liver Physiol. 2015;309(4):G270-8. PMCID: PMC4537925.


Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ. Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin. J Cell Sci. 2015 Sep 15;128(18):3444-55. PubMed PMID: 26272915; PubMed Central PMCID: PMC4582402.


Soutto M, Romero-Gallo J, Krishna U, Piazuelo MB, Washington MK, Belkhiri A, Peek RM Jr, El-Rifai W. Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis. Oncotarget. 2015 Jul 20;6(20):17911-22. PubMed PMID: 25980439; PubMed Central PMCID: PMC4627225.


Taylor C, Loomans HA, Le Bras GF, Koumangoye RB, Romero-Morales AI, Quast LL, Zaika AI, El-Rifai W, Andl T, Andl CD. Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma. Oncotarget. 2015 Oct 27;6(33):34228-44. PubMed PMID: 26447543; PubMed Central PMCID: PMC4741448.


Teo AK, Tsuneyoshi N, Hoon S, Tan EK, Stanton LW, Wright CV, Dunn NR. PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells. Stem Cell Reports. 2015;4(4):578-90. PMCID: PMC4400640


Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W. Cloning and variation of ground state intestinal stem cells. Nature. 2015;522(7555):173-8. PMCID: PMC4853906.


Wang Y, Shi C, Lu Y, Poulin EJ, Franklin JL, Coffey RJ. Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia. Am J Pathol. 2015 Apr;185(4):1123-34. PubMed PMID: 25794708; PubMed Central PMCID: PMC4380843.


Ahmad R, Chaturvedi R, Olivares-Villagemez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol, 2014; 7:1340-53. PMCID: PMC4221190.


Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KLJ. Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab, 2014; 4:58-63. PMCID: PMC4314532.


Buckman, L. B., Anderson-Baucum, E. K., Hasty, A. H., and Ellacott, K. Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte,2014; 3, 215-220 PMC4110099


Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut, 2014 Jan 31; Epub ahead of print. 63: 1711-20. PMCID: PMC4117823.


Crawley SW, Shifrin DA Jr, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, Tyska MJ. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell, 2014; 157:433-46. PMCID: PMC3992856.


Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol Metab. 2014;3(5):544-53. PMCID: PMC4099508.


Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM. The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration. PLoS Pathog, 2014; 10:e1004450. doi: 10.1371/journal.ppat.1004450. PMCID: PMC4199781.


Gerard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell. 2014;158(3):492-505. PMCID: PMC4119593.


Haley KP, Blanz EJ, Gaddy JA. High resolution electron microscopy of the Helicobacter pylori Cag type IV secretion system pili produced in varying conditions of iron availability. J Vis Exp. 2014;(93):e52122. PMCID: PMC4354248.


Johnson EM, Gaddy JA, Voss BJ, Hennig EE, Cover TL. Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system. Infect Immun, 2014; 82:3457-70. PMCID: PMC4136203.


Knowles BC, Roland JT, Krishnan M, Tyska MJ, Lapierre LA, Dickman PS, Goldenring JR, Shub MD. Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease. J Clin Invest, 2014; 124:2947-62. PMCID: PMC4071383.


Le Bras GF, Loomans HA, Taylor CJ, Revetta FL, Andl CD. Activin A balance regulates epithelial invasiveness and tumorigenesis. Lab Invest, 2014; 94:1134-46. PMCID: PMC4309391.


Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD. Enhanced synthesis of saturated hospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. J Lipid Res, 2014; 55:1478-1488. PMCID: PMC4076085.


Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest. 2014 May;124(5):2172-87. PMCID: PMC4001536.


Mason, T. A., Goldenring, J. R., and Kolobova, E. AKAP350C targets to mitochondria via a novel amphipathic alpha helical domain. Cellular logistics, 2014; 4, e943597 PMC4279805


Mazerik JN, Kraft LJ, Kenworthy AK, Tyska MJ. Motor and tail homology 1 (th1) domains antagonistically control myosin-1 dynamics. Biophys J, 2014; 106:649-58. PMCID: PMC3944834.


Noto JM, Lee JY, Gaddy JA, Cover TL, Amieva MR, Peek RM Jr. Regulation of Helicobacter pylori virulence within the context of iron deficiency. J Infect Dis. 2014 Dec 11. pii: jiu805. 211: 1790-4. PMCID: PMC4447831.


Petersen CP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology, 2014; 146:1727-38. PMCID: PMC4035414.


Pope, J. L., Bhat, A. A., Sharma, A., Ahmad, R., Krishnan, M., Washington, M. K., Beauchamp, R. D., Singh, A. B., and Dhawan, P. Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Gut, 2014; 63, 622-634 PMC4083824


Radin JN, Gonzalez-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun, 2014; 82:423-32. PMCID: PMC3911829.


Schafer JC, Baetz NW, Lapierre LA, McRae RE, Roland JT, Goldenring JR. Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic, 2014; 15:292-308. PMCID: PMC4081500.


Voss BJ, Gaddy JA, McDonald WH, Cover TL. Analysis of surface-exposed outer membrane proteins in Helicobacter pylori. J Bacteriol, 2014; 196:2455-71. PMCID: PMC4054173.


Wang L, Cao H, Liu L, Wang B, Walker WA, Acra SA, Yan F. Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein. J Biol Chem, 2014; 289:20234-44. PMCID: PMC4106339.


Weis VG, Petersen CP, Mills JC, Tuma PL, Whitehead RH, Goldenring JR. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol, 2014; 307:G777-92. PMCID: PMC4200317.


Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014; 33:1882-95. PMCID: PMC4195784.


Baetz NW, Goldenring JR. Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system. Mol Biol Cell, 2013; 24:643-58. PMCID: PMC3583667.


Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Jr., Cover TL, Solnick JV. Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog, 2013; 9:e1003189. PMCID: PMC3585145.


Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ. Proteomic analysis of exosomes from mutant Kras colon cancer cells identifies intercellular transfer of mutant Kras. Mol Cell Proteomics, 2013; 12:343-55. PMCID: 3567858.


Gobert AP, Verriere T, de Sablet T, Peek RM, Jr., Chaturvedi R, Wilson KT. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell Microbiol, 2013; 15:145-56. PMCID: 3524338.


Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W. Aurora kinase a promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology, 2013; 145:1312-22 e1-8. PMCID: PMC3840093.


Krishnan M, Lapierre LA, Knowles BC, Goldenring JR. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell, 2013; 24:818-31. PMCID: PMC3596252.


Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. Specification of hepatopancreas progenitors in zebrafish by Hnf1ba and Wnt2bb. Development, 2013; 140:2669-79. PMCID: PMC3678338.


Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM, Jr. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest, 2013; 123:479-92. PMCID: 3533289.


Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development, 2013; 140:751-64. PMCID: 3557774.


Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WX, Zhang J, Van Kaer L. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of vps34. J Immunol, 2013; 190:5086-101. PMCID: PMC3646937.


Radin JN, Gaddy JA, Gonzalez-Rivera C, Loh JT, Algood HM, Cover TL. Flagellar localization of a Helicobacter pylori autotransporter protein. MBio, 2013; 4:e00613-12. PMCID: PMC3622936.


Sethman CR, Hawiger J. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PLoS One. 2013; 8(7):e70994. PMCID: PMC3726548.


Sharma A, Bhat AA, Krishnan M, Singh AB, Dhawan P. Trichostatin-a modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. Carcinogenesis, 2013; 34:2610-21. PMCID: PMC3810835.


Shelton EL, Poole SD, Reese J, Bader DM. Omental grafting: A cell-based therapy for blood vessel repair. J Tissue Eng Regen Med, 2013; 7:421-33. PMCID: PMC3672266.


Singh B, Bogatcheva G, Washington MK, Coffey RJ. Transformation of polarized epithelial cells by apical mistrafficking of epiregulin. Proc Natl Acad Sci U S A, 2013; 110:8960-5. PMCID: PMC3670353.


von Figura G, Morris JPt, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic KRAS-mediated pancreatic neoplastic initiation. Gut, 2013; PMCID: PMC3883808.


Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, et al. Necrotising enterocolitis is characterized by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) Tcell ratios. Gut, 2013; 62:73-82. PMCID: PMC3606820.


Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (Foxp3)/effector (CD4, CD8) T cell ratios. Gut, 2013; 62:73-82. PMCID: PMC3606820.


Wiese CB, Fleming NL, Buehler DP, Southard-Smith EM. A Uchl1-H2BmonoCherry:EGFP-GPI BAC transgene for imaging neuronal progenitors. Genesis. 2013; 51:852-861. PMCID: PMC3953494.


Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Jr., Wilson KT, Hiebert SW. Mtg16 contributes to colonic epithelial integrity in experimental colitis. Gut, 2013; 62:1446-55. PMCID: PMC3663894.


Anderson EK, Hill AA, Hasty AH. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. Arterioscler Thromb Vasc Biol, 2012; 32:1687-95. PMCID: 3385654.


Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W. Resistance to trail is mediated by Darpp-32 in gastric cancer. Clin Cancer Res, 2012; 18:3889-900. PMCID: 3399047.


Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. Xiap monoubiquitylates groucho/tle to promote canonical Wnt signaling. Mol Cell, 2012; 45:619-28. PMCID: 3299836.


Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF. Production of Selenoprotein p (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem, 2012; 287:40414-24. PMCID: 3504756.


Johnson EM, Gaddy JA, Cover TL. Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells. Front Cell Infect Microbiol. 2012; 2():17. PMCID: PMC3417513.


Kim TI, Poulin EJ, Blask E, Bukhalid R, Whitehead RH, Franklin JL, Coffey RJ. Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized caco-2 cells. Growth Factors, 2012; 30:320-32. PMCID: 3594790.


Lapierre, L. A., Avant, K. M., Caldwell, C. M., Oztan, A., Apodaca, G., Knowles, B. C., Roland, J. T., Ducharme, N. A., and Goldenring, J. R. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Molecular Biology of the Cell, 2012; 23, 2302-2318 PMC3374749


Lapierre, L. A., Ducharme, N. A., Drake, K. R., Goldenring, J. R., and Kenworthy, A. K. Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. Experimental Cell Research, 2012; 318, 103-113 PMC3230713


Le Bras GF, Taubenslag KJ, Andl CD. The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh Migr, 2012; 6:365-73. PMCID: 3478259.


Mazerik JN, Tyska MJ. Myosin-1a targets to microvilli using multiple membrane binding motifs in the tail homology 1 (th1) domain. J Biol Chem, 2012; 287:13104-15. PMCID: 3339983.


MohanKumar K, Kaza N, Jagadeeswaran R, Garzon SA, Bansal A, Kurundkar AR, Namachivayam K, Remon JI, Bandepalli CR, Feng X, Weitkamp JH, Maheshwari A. Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: Evidence from an animal model. Am J Physiol Gastrointest Liver Physiol, 2012; 303:G93-102. PMCID: 3404576.


Mundell, N. A., Plank, J. L., LeGrone, A. W., Frist, A. Y., Zhu, L., Shin, M. K., Southard-Smith, E. M., and Labosky, P. A. Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Developmental Biology, 2012; 363, 373-387 PMC3288190


Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut, 2012; 61:1250-60. PMCID: 3419307.


Pound, L. D., Sarkar, S. A., Ustione, A., Dadi, P. K., Shadoan, M. K., Lee, C. E., Walters, J. A., Shiota, M., McGuinness, O. P., Jacobson, D. A., Piston, D. W., Hutton, J. C., Powell, D. R., and O'Brien, R. M. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PloS One, 2012; 7, e40972 PMC3400647


Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ. The pan-ErbB negative regulator LRIG1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell, 2012; 149:146-58. PMCID: 3563328.


Shifrin DA, Jr., McConnell RE, Nambiar R, Higginbotham JN, Coffey RJ, Tyska MJ. Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol, 2012; 22:627-31. PMCID: 3326206.


Singh AB, Sharma A, Dhawan P. Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner. Carcinogenesis, 2012; 33:2538-47. PMCID: 3510734.


Smith AL, Dohn MR, Brown MV, Reynolds AB. Association of rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell, 2012; 23:99-110. PMCID: 3248908.


Thomason RT, Bader DM, Winters NI. Comprehensive timeline of mesodermal development in the quail small intestine. Dev Dyn, 2012; 241:1678-94. PMCID: 3475750.


Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology, 2012; 55:233-43. PMCID: 3235248.


Winters NI, Thomason RT, Bader DM. Identification of a novel developmental mechanism in the generation of mesothelia. Development. 2012;139(16):2926-34. PMCID: PMC3403102.


Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A, 2012; 109:E1143-52. PMCID: 3358828.


Zhang Y, Dube PE, Washington MK, Yan F, Polk DB (2012) Erbb2 and Erbb3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest, 2012; 92:437-50. PMCID: 3289719.


Corpening JC, Deal KK, Cantrell VA, Skelton SB, Buehler DP, Southard-Smith EM. Isolation and live imaging of enteric progenitors based on Sox10-Histone2BVenus transgene expression. Genesis. 2011; 49(7):599-618. PMCID: PMC3212811.


Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: Role of epidermal growth factor receptor activation. Oncogene, 2011; 30:3234-47 PMCID: 3591522.


Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Jr., Polk DB. TNF-alpha converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol, 2011; 301:G338-46. PMCID: 3154600.


Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. Tnf transactivation of EGFR stimulates cytoprotective Cox-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol,2011; 301:G220-9. PMCID: 3154604.


Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL. Inhibiting CXCR2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 2011; 121:4106-17. PMCID: 3195452.


Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken). 2011;68(2):97-111. PMCID: PMC3885764.


Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell, 2011; 10:996-1010. PMCID: 3215833.


Liu Y, Bertram CC, Shi Q, Zinkel SS. Proapoptotic bid mediates the ATR-directed DNA damage response to replicative stress. Cell Death Differ, 2011; 18:841-52. PMCID: 3074003.


Mason TA, Kolobova E, Liu J, Roland JT, Chiang C, Goldenring JR. Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. PLoS One. 2011; 6(11):e27699. PMCID: PMC3216988.


Radin JN, Gonzalez-Rivera C, Ivie SE, McClain MS, Cover TL. Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells. Infect Immun, 2011; 79:2535-43. PMCID: 3191986.


Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR. Rab gtpase-myo5b complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A, 2011; 108:2789-94. PMCID: 3041130.


Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS. Bves modulates tight junction associated signaling. PLoS One, 2011; 6:e14563. PMCID: 3024319.


Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P. Claudin-1 up-regulates the repressor zeb-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology, 2011; 141:2140-53. PMCID: 3395068.


Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT. The apolipoprotein e-mimetic peptide cog112 inhibits NF-kB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem, 2011; 286:3839-50. PMCID: 3030385.


Smalley-Freed WG, Efimov A, Short SP, Jia P, Zhao Z, Washington MK, Robine S, Coffey RJ, Reynolds AB. Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One, 2011; 6:e19880. PMCID: 3096651.


Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell, 2011; 19:470-83. PMCID: 3077713.


Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol, 2011; 6:452-65. PMCID: 3401128.


Van Raay TJ, Fortino NJ, Miller BW, Ma H, Lau G, Li C, Franklin JL, Attisano L, Solnica-Krezel L, Coffey RJ. Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of beta-catenin. PLoS One, 2011; 6:e18650. PMCID: 3072412.


Vangamudi B, Zhu S, Soutto M, Belkhiri A, El-Rifai W. Regulation of beta-catenin by T-Darpp in upper gastrointestinal cancer cells. Mol Cancer, 2011; 10:32. PMCID: 3075216.


Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS. Bves regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, 2011; 121:4056-69. PMCID: 3195453.


Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika AI. P73 protein regulates DNA damage repair. FASEB J, 2011; 25:4406-14. PMCID: 3236618.


Fung CM, White JR, Brown AS, Gong H, Weitkamp JH, Frey MR, McElroy SJ. Intrauterine Growth Restriction Alters Mouse Intestinal Architecture during Development. PLoS One. 2016;11(1):e0146542/ PMCID: PMC4706418.


Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagemez D, Barry DP, Allaman MM, Washington MK, Peek RM, Jr., Piazuelo MB, Wilson KT. EGFR regulates macrophage polarization and function in bacterial infection. J Clin Invest. In Press, accepted 6/2/16, NIHMSID: NIHMS777921.


McKenzie AJ, Hoshino D, Hong NH, Cha DJ, Franklin JL, Coffey RJ, Patton JG, Weaver AM. KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. Cell Rep. 2016;15(5):978-87. PMCID: PMC4857875.


Choi E, Petersen CP, Lapierre LA, Williams JA, Weis VG, Goldenring JR, Nam KT. Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin. Am J Pathol. 2015;185(8):2219-31. PMCID: PMC4530133.


Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Sci Signal. 2015;8(407):ra129. PMCID: PMC4812576.


Mendonsa AM, VanSaun MN, Ustione A, Piston DW, Fingleton BM, Gorden DL. Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver. Mol Cancer. 2015;14():49. PMCID: PMC4351934.


Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT. Biogenesis, delivery, and function of extracellular RNA. J Extracell Vesicles. 2015;4():27494. PMCID: PMC4553266.


Salaria S, Means A, Revetta F, Idrees K, Liu E, Shi C. Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. Am J Clin Pathol. 2015 Oct;144(4):642-8. PubMed PMID: 26386086; NIHMSID: NIHMS668403; PubMed Central PMCID: PMC4576728.


Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Mol Syst Biol. 2015 Oct 30;11(10):835. PubMed PMID: 26519361; PubMed Central PMCID: PMC4631206.


Stengel KR, Zhao Y, Klus NJ, Kaiser JF, Gordy LE, Joyce S, Hiebert SW, Summers AR. Histone Deacetylase 3 Is Required for Efficient T Cell Development. Mol Cell Biol. 2015 Nov;35(22):3854-65. PubMed PMID: 26324326; PubMed Central PMCID: PMC4609739.


Aiyegbo MS, Eli IM, Spiller BW, Williams DR, Kim R, Lee DE, Liu T, Li S, Stewart PL, Crowe JE. Differential accessibility of a rotavirus VP6 epitope in trimers comprising type I, II, or III channels as revealed by binding of a human rotavirus VP6-specific antibody. J Virol. 2014; 88(1):469-76. PMCID: PMC3911710.


Anderson-Baucum EK, Major AS, Hasty AH. A possible secondary immune response in adipose tissue during weight cycling: The ups and downs of yo-yo dieting. Adipocyte. 2014; 3(2):141-5. PMCID: PMC3979879.


Buckman LB, Hasty AH, Flaherty DK, Buckman CT, Thompson MM, Matlock BK, Weller K, Ellacott KL. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun 2014; 35:33-42. PMCID: PMC3858467.


Carbo A, Olivares-Villagemez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio, 2014; 5:e01243-14. PMCID: PMC4120195.


Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA Jr, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM Jr, Wilson KT. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology, 2014; 146:1739-51. PMCID: PMC4035375.


Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM Jr, Fox JG, Woster PM, Casero RA Jr, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene, 2014; doi: 10.1038/onc.2014.273. [Epub ahead of print] PMCID: PMC4345146.


DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS One. 2014; 9(10):e110183. PMCID: PMC4203769.


Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM Jr, Chaturvedi R, Wilson KT. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J Immunol, 2014; 193:3013-22. PMCID: PMC4171064.


Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, Fordahl SC, Erikson KM, Zhang Y, Etzerodt A, Moestrup SK, Hasty AH. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes, 2014; 63:421-32. PMCID: PMC3900546.


Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Meller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metab, 2014; 20:1018-29 PMCID: PMC4255280.


Poulin EJ, Powell AE, Wang Y, Li Y, Franklin JL, Coffey RJ. Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine. Stem Cell Res, 2014; 13(3 Pt A):422-30. PMCID: PMC4320017.


Scheving LA, Zhang X, Garcia OA, Wang RF, Stevenson MC, Threadgill DW, Russell WE. Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. Am J Physiol Gastrointest Liver Physiol, 2014; 306:G370-81. PMCID: PMC3949019.


Soutto M, Chen Z, Saleh MA, Katsha A, Zhu S, Zaika A, Belkhiri A, El-Rifai W. TFF1 activates p53 through down-regulation of miR-504 in gastric cancer. Oncotarget. 2014; 5(14):5663-73. PMCID: PMC4170596.


Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P, Denning PW. Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing entercolitis. PLoS One, 2014; 9 (6) e99042. PMCID: PMC4048281.


Winters NI, Williams AM, Bader DM. Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis. Dev Biol. 2014;391(2):125-32. PMCID: PMC4037704.


Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM Jr. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. 2014 Aug 14. pii:gutjnl-2014-307650. doi: 10.1136/gutjnl-2014-307650. [Epub ahead of print] PMCID: PMC4329117.


Wu L, Parekh VV, Hsiao J, Kitamura D, Van Kaer L . Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance. Proc Natl Acad Sci U S A., 2014; 111(43):E4638-47. doi: 10.1073/pnas.1324052111. Epub 2014 Oct 13. PMCID: PMC4217427.


Yang Z, Sun D, Yan Z, Reynolds AB, Christman JW, Minshall RD, Malik AB, Zhang Y, Hu G. Differential role for p120-catenin in regulation of TLR4 signaling in macrophages. J Immunol. 2014; 193(4):1931-41. PMCID: PMC4119481.


Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014;33(17):1882-95. PMCID: PMC4195784.


Zhang B, Chen X, Bae S, Singh K, Washington MK, Datta PK. Loss of smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating AKT pathway. Br J Cancer, 2014; 110:946-57. PMCID: PMC3929873.


Aiyegbo MS, Sapparapu G, Spiller BW, Eli IM, Williams DR, Kim R, Lee DE, Liu T, Li S, Woods VL, Nannemann DP, Meiler J, Stewart PL, Crowe JE. Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore. PLoS One. 2013; 8(5):e61101. PMCID: PMC3650007.


Anderson EK, Gutierrez DA, Kennedy A, Hasty AH. Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes, 2013; 62:3180-8. PMCID: PMC3749340.


Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res. 2013; 73(3):1245-55.PMCID: PMC3563732.


Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS One, 2013; 8:e82300. PMCID: PMC3867379.


Farrow MA, Chumbler NM, Lapierre LA, Franklin JL, Rutherford SA, Goldenring JR, Lacy DB. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc Natl Acad Sci U S A, 2013; 110:18674-9. PMCID: PMC3831945.


Franklin JL, Rankin CR, Levy S, Snoddy JR, Zhang B, Washington MK, Thomson JM, Whitehead RH, Coffey RJ. Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA. Biochem Biophys Res Commun, 2013. 440:99-104. PMCID: PMC3875348.


Horvath DJ, Jr., Radin JN, Cho SH, Washington MK, Algood HM The interleukin-17 receptor B subunit is essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. PLoS One, 2013; 8:e60363. PMCID: PMC3606319.


Hoshino D, Kirkbride KC, Costello K, Clark ES, Sinha S, Grega-Larson N, Tyska MJ, Weaver AM Exosome secretion is enhanced by invadopodia and drives invasive behavior. Cell Rep: 2013 Dec 12; 5:1159-68. PMCID: PMC3873329.


Kennedy A, Webb CD, Hill AA, Gruen ML, Jackson LG, Hasty AH. Loss of CCR5 results in glucose intolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2013;305(7):E897-906. PMCID: PMC3798705.


Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integr Biol (Camb). 2013; 5(11):1355-65. PMCID: PMC3966991.


Leamy AK, Egnatchik RA, Young JD. Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Prog Lipid Res. 2013; 52(1):165-74. PMCID: PMC3966991.


Liu J, Willet SG, Bankaitis ED, Xu Y, Wright CV, Gu G. Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis. 2013; 51(6):436-42. PMCID: PMC3696028.


Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM, Jr. Helicobacter pylori promotes the expression of Kruppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One, 2013; 8:e54344. PMCID: 3553174.


Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM, Jr. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein MCl-1. Am J Physiol Gastrointest Liver Physiol, 2013; 305:G786-96. PMCID: PMC3882435.


Orr JS, Kennedy AJ, Hasty AH. Isolation of adipose tissue immune cells. J Vis Exp, 2013; e50707. PMID: 23728515. PMCID: PMC3718226.


Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y. N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways. Nat Commun. 2013; 4():1589. PMCID: PMC3602931.


Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Jr., Wilson KT. Stat6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol, 2013; 190:1849-58. PMCID: PMC3563924.


Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Cancer, 2013; 119:904-14. PMCID: 3524359.


Sheh A, Chaturvedi R, Merrell DS, Correa P, Wilson KT, Fox JG. Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells. Infect Immun, 2013; 81:2468-77. PMCID: PMC3697613.


Sierra JC, Hobbs S, Chaturvedi R, Yan F, Wilson KT, Peek RM, Jr., Polk DB. Induction of cox-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2013; 305:G196-203. PMCID: PMC3725681.


Van Kaer L, Rabacal WA, Scott Algood HM, Parekh VV, Olivares-Villagomez D. In vitro induction of regulatory CD4+CD8alpha+ T cells by TGF-beta, IL-7 and IFN-gamma. PLoS One, 2013; 8:e67821. PMCID: PMC3701067.


Wang L, Cao H, Lu N, Liu L, Wang B, Hu T, Israel DA, Peek RM, Polk DB, Yan F. Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One. 2013;8(2):e56666. PMCID: PMC3573001.


Ahnfelt-Renne J, Jergensen MC, Klinck R, Jensen JN, Fechtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P. Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development., 2012; 139(1):33-45. PMCID: PMC3231770.


Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One, 2012; 7:e51205. PMCID: 3521008.


Buehler DP, Buehler D, Wiese CB, Wiese C, Skelton SB, Southard-Smith EM, Southard-Smith M. An optimized procedure for fluorescence-activated cell sorting (FACS) isolation of autonomic neural progenitors from visceral organs of fetal mice. J Vis Exp. 2012;(66):e4188. PMCID: PMC3671830.


Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids, 2012; 42:627-40. PMCID: 3258477.


Chaturvedi R, de Sablet T, Peek RM, Wilson KT. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes, 2012; 3:48-56. PMCID: 3337125.


Dwivedi VP, Tousif S, Bhattacharya D, Prasad DV, Van Kaer L, Das J, Das G. Transforming growth factor-beta protein inversely regulates in vivo differentiation of interleukin-17 (il-17)-producing CD4+ and CD8+ t cells. J Biol Chem, 2012; 287:2943-7. PMCID: 3270951.


Gonzalez-Rivera C, Algood HM, Radin JN, McClain MS, Cover TL . The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay. Infect Immun, 2012; 80:2578-88. PMCID: 3434591.


Gutierrez DA, Hasty AH. Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. J Endocrinol. 2012;212(3):343-51. PMCID: PMC3381898.


Kennedy A, Gruen ML, Gutierrez DA, Surmi BK, Orr JS, Webb CD, Hasty AH. Impact of macrophage inflammatory protein-1alpha deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. PLoS One, 2012; 7:e31508. PMCID: 3281060.


Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab Invest. 2012; 92(12):1749-59. PMCID: PMC3510327.


Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol. 2012; 362(1):57-64. PMCID: PMC3254730.


Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JPt, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell, 2012; 22:737-50. PMCID: 3568632.


Kumagai H, Pham W, Kataoka M, Hiwatari KI, McBride J, Wilson KJ, Tachikawa H, Kimura R, Nakamura K, Liu EH, Gore JC, Sakuma S (2012) Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer. Int J Cancer, 132:2107-17. PMCID: 3566327.


Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe, 2012; 11:227-39. PMCID: 3308348.


Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes, 2012; 61:2718-27. PMCID: 3478520.


Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis. 2012; 50(4):384-92. PMCID: PMC3870909.


Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One, 2012; 7:e36418. PMCID: 3344856.


Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Jr., Correa P, Gobert AP, Polk DB, Peek RM, Jr., Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 2011; 141:1696-708 e1-2. PMCID: 3202654.


Ducharme NA, Ham AJ, Lapierre LA, Goldenring JR. Rab11-FIP2 influences multiple components of the endosomal system in polarized MDCK cells. Cell Logist. 2011;1(2):57-68. PMCID: PMC3116584.


Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Felsch H, Coffey RJ. Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin. Traffic. 2011;12(12):1793-804. PMCID: PMC3886124.


Goettel JA, Scott Algood HM, Olivares-Villagomez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. Ksr1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-gamma production. Gastroenterology, 2011; 140:265-74. PMCID: 3008308.


Gutierrez DA, Kennedy A, Orr JS, Anderson EK, Webb CD, Gerrald WK, Hasty AH. Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity. Diabetes. 2011; 60(11):2820-9. PMCID: PMC3198070.


Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagomez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H. Mucosal memory CD8(+) t cells are selected in the periphery by an MHC class I molecule. Nat Immunol, 2011; 12:1086-95. PMCID: 3197978.


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Reddy VK, Short SP, Barrett CW, Mittal MK, Keating CE, Thompson JJ, Harris EI, Revetta F, Bader DM, Brand T, Washington MK, Williams CS. BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation. Stem Cells. 2016 Feb 17;34: 1626-36. PMCID: PMC4893006.


Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Sci Rep. 2016 Jan 5;6:18594. PubMed PMID: 26729566; PubMed Central PMCID: PMC4700446.


Zahm CD, Szulczewski JM, Leystra AA, Paul Olson TJ, Clipson L, Albrecht DM, Middlebrooks M, Thliveris AT, Matkowskyj KA, Washington MK, Newton MA, Eliceiri KW, Halberg RB. Advanced Intestinal Cancers often Maintain a Multi-Ancestral Architecture. PLoS One. 2016;11(2):e0150170. PMCID: PMC4769224.


French CL, Ye F, Revetta F, Zhang B, Coffey RJ, Washington MK, Deane NG, Beauchamp RD, Weaver AM. Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness. F1000Res. 2015; 4:99. PubMed PMID: 26097693; PubMed Central PMCID: PMC4457132.


Garcia AE, Kasim N, Tamboli RA, Gonzalez RS, Antoun J, Eckert EA, Marks-Shulman PA, Dunn J, Wattacheril J, Wallen T, Abumrad NN, Flynn CR. Lipoprotein Profiles in Class III Obese Caucasian and African American Women with Nonalcoholic Fatty Liver Disease. PLoS One. 2015; 10(11):e0142676. PubMed PMID: 26599819; PubMed Central PMCID: PMC4657895.


Haley KP, Delgado AG, Piazuelo MB, Mortensen BL, Correa P, Damo SM, Chazin WJ, Skaar EP, Gaddy JA. The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence. Infect Immun. 2015 Jul;83(7):2944-56. PubMed PMID: 25964473; PubMed Central PMCID: PMC4468547.


Jin M, Roth R, Rock JB, Washington MK, Lehman A, Frankel WL. The impact of tumor deposits on colonic adenocarcinoma AJCC TNM staging and outcome. Am J Surg Pathol. 2015 Jan;39(1):109-15. PubMed PMID: 25229767; NIHMSID: NIHMS614917; PubMed Central PMCID: PMC4267920.


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Knowles BC, Weis VG, Yu S, Roland JT, Williams JA, Alvarado GS, Lapierre LA, Shub MD, Gao N, Goldenring JR. Rab11a regulates Syntaxin 3 localization andmicrovillus assembly in enterocytes. J Cell Sci; 2015 Feb 11. pii: jcs.163303. 128: 1617-26. PMCID: PMC4518445.


McKinley ET, Watchmaker JM, Chakravarthy AB, Meyerhardt JA, Engelman JA, Walker RC, Washington MK, Coffey RJ, Manning HC. [(18)F]-FLT PET to predict early response to neoadjuvant therapy in KRAS wild-type rectal cancer: a pilot study. Ann Nucl Med. 2015; 29(6):535-42. PMCID: PMC4503488.


Moore BD, Jin RU, Osaki L, Romero-Gallo J, Noto J, Peek RM, Mills JC. Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Am J Physiol Gastrointest Liver Physiol. 2015;309(12):G955-64. PMCID: PMC4683299.


Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar;29(3):786-95. PubMed PMID: 25398765; PubMed Central PMCID: PMC4763883.


Sakuma S, Yu JY, Quang T, Hiwatari K, Kumagai H, Kao S, Holt A, Erskind J, McClure R, Siuta M, Kitamura T, Tobita E, Koike S, Wilson K, Richards-Kortum R, Liu E, Washington K, Omary R, Gore JC, Pham W. Fluorescence-based endoscopic imaging of Thomsen-Friedenreich antigen to improve early detection of colorectal cancer. Int J Cancer. 2015 Mar 1;136(5):1095-103. PubMed PMID: 25052906; NIHMSID: NIHMS617824; PubMed Central PMCID: PMC4268149.


Salleng KJ, Revetta FL, Deane NG, Washington MK. The Applicability of a Human Immunohistochemical Panel to Mouse Models of Hepatocellular Neoplasia. Comp Med. 2015 Oct;65(5):398-408. PubMed PMID: 26473343; PubMed Central PMCID: PMC4617330.


Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM Jr, Belkhiri A, El-Rifai WM. Trefoil factor 1 expression suppresses Helicobacter pylori induced inflammation in gastric carcinogenesis. Cancer. 2015 Dec 15;121(24):4348-58. PubMed PMID: 26372254; NIHMSID: NIHMS713494; PubMed Central PMCID: PMC4670586.


Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ. IL-33 Signaling protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. Inflamm Bowel Dis. 2015 Dec;21(12):2737-46. PubMed PMID: 26313694; NIHMSID: NIHMS698252; PubMed Central PMCID: PMC4654638.


Wainright KS, Fleming NJ, Rowles JL, Welly RJ, Zidon TM, Park YM, Gaines TL, Scroggins RJ, Anderson-Baucum EK, Hasty AH, Vieira-Potter VJ, Padilla J. Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R594-602. PubMed PMID: 26180183;PubMed Central PMCID: PMC4591377.


Williams CS, Bernard JK, Demory Beckler M, Almohazey D, Washington MK, Smith JJ, Frey MR. ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis. 2015 Jul;36(7):710-8. PubMed PMID: 25916654; PubMed Central PMCID: PMC4572918.


Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, El-Rifai W. Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis. Oncogene. 2015 Jun 29;PubMed PMID: 26119931; NIHMSID: NIHMS694155; PubMed Central PMCID: PMC4486340.


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Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP. Acetate dependence of tumors. Cell. 2014 Dec 18;159(7):1591-602. PMCID: PMC4272450.


Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, J RS, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology, 2014; 146:233-44 e5. PMCID: PMC3870045.


Gonzalez RS, Liu EH, Alvarez JR, Ayers GD, Washington MK, Shi C. Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors? Mod Pathol, 2014; 27: 1288-95. PMCID: PMC4110189.


Gopal P, Lu P, Ayers GD, Herline AJ, Washington MK. Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis. Mod Pathol, 2014; p 27: 1281-7. PMCID: PMC4230335.


Katsha A, Arras J, Soutto M, Belkhiri A, El-Rifai W. AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Mol Oncol. 2014;8(8):1419-28. PMCID: PMC4254172.


Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Jr., Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A, 2014; 111:1455-60. PMCID: PMC3910595.


Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM Jr. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene, 2014; doi: 10.1038/onc.2014.135. [Epub ahead of print] PMCID: PMC4237684.


Le Bras GF, Taylor C, Koumangoye RB, Revetta F, Loomans HA, Andl CD. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Exp Cell Res, 2014; 330:29-42. PMCID: PMC4267897.


Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dube PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J Immunol, 2014; 192:1013-23. PMCID: PMC4006992.


McKinley ET, Zhao P, Coffey RJ, Washington MK, Manning HC. 3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. PLoS One. 2014;9(9):e108193. PMCID: PMC4172755.


Mikhitarian K, Pollen M, Zhao Z, Shyr Y, Merchant NB, Parikh A, Revetta F, Washington MK, Vnencak-Jones C, Shi C. Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. Mod Pathol, 2014; 27:665-74. PMCID: PMC4007414.


Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB. Novel mechanistic insights into ectodomain shedding of EGFR ligands amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Cancer Res, 2014; 74:2062-72. PMCID: PMC3975694.


Otero YF, Lundblad TM, Ford EA, House LM, McGuinness, OP. Liver but not adipose tissue is responsive to the pattern of enteral feeding. Physiological Reports, 2014; 2; (2) e00250. PMCID: PMC3966249.


Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant N, Maitra A, Means AL, Gannon M. Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab Invest, 2014; 94:517-27.PMCID: PMC4068339.


Ray KC, Moss ME, Franklin JL, Weaver CJ, Higginbotham J, Song Y, Revetta FL, Blaine SA, Bridges LR, Guess KE, Coffey RJ, Crawford HC, Washington MK, Means AL. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated KRAS to promote rapid onset of pancreatic neoplasia. Oncogene, 2014; 33:823-31. PMCID: PMC3929321.


Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. Hdm2 regulation by AURKA promotes cell survival in gastric cancer. Clin Cancer Res, 2014; 20:76-86. PMCID: PMC3947328.


Shi C, Merchant N, Newsome G, Goldenberg DM, Gold DV. Differentiation of pancreatic ductal adenocarcinoma from chronic pancreatitis by Pam4 immunohistochemistry. Arch Pathol Lab Med, 2014; 138:220-8. PMCID: PMC4037743.


Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest, 2014; 94:409-21. PMCID: PMC3992484.


Tripathi MK, Deane NG, Zhu J, An H, Mima S, Wang X, Padmanabhan S, Shi Z, Prodduturi N, Ciombor KK, Chen X, Washington MK, Zhang B, Beauchamp RD. Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer. Cancer Res, 2014; 74:6947-57. PMCID: PMC4252979.


Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J Pharmacol Exp Ther. 2014;351(3):549-58. PMCID: PMC4244585.


Wei J, Noto JM, Zaika E, Romero-Gallo J, Piazuelo MB, Schneider B, El-Rifai W, Correa P, Peek RM, Zaika A. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut. 2014 Jul 30. pii: gutjnl-2014-307295. doi: 10.1136/gutjnl-2014-307295. [Epub ahead of print] PMCID: PMC4312278.


Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PLoS One, 2013; 8:e69660. PMCID: PMC3726759.


Ausborn NL, Wang T, Wentz SC, Washington MK, Merchant NB, Zhao Z, Shyr Y, Chakravarthy AB, Xia F. 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma. BMC Cancer. 2013;13():155. PMCID: PMC3636043.


Chen Z, Saad R, Jia P, Peng D, Zhu S, Washington MK, Zhao Z, Xu Z, El-Rifai W. Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma. Cancer, 2013; 119:1985-93. PMCID: PMC3731210.


Deming DA, Leystra AA, Farhoud M, Nettekoven L, Clipson L, Albrecht D, Washington MK, Sullivan R, Weichert JP, Halberg RB. mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers. PLoS One. 2013;8(4):e60709. PMCID: PMC3621889.


Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Jr., Algood HM, Cover TL. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun, 2013; 81:2258-67. PMCID: PMC3676043.


Hansen AG, Freeman TJ, Arnold SA, Starchenko A, Jones-Paris CR, Gilger MA, Washington MK, Fan KH, Shyr Y, Beauchamp RD, Zijlstra A. Elevated Alcam shedding in colorectal cancer correlates with poor patient outcome. Cancer Res, 2013; 73:2955-64. PMCID: PMC3660148.


Hight M, Cheung Y, Nickels M, Dawson E, Zhao P, Saleh S, Buck J, Tang D, Washington MK, Coffey RJ, Manning HC. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Clin Cancer Res, 2013; In Press. 2014 Apr 15;20(8):2126-35 PMCID: PMC3989451


Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M, Bor D, Froeling FE, Bhattacharya S, Rustgi AK, Sahai E, Chelala C, Sasieni P, Kocher HM. Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol, 2013; 230:107-17. PMCID: PMC4034674.


Lim J, Duong T, Do N, Do P, Kim J, Kim H, El-Rifai W, Ruley HE, Jo D. Antitumor activity of cell-permeable Runx3 protein in gastric cancer cells. Clin Cancer Res, 2013; 19:680-90. PMCID: PMC4039637.


McKinley ET, Ayers GD, Smith RA, Saleh SA, Zhao P, Washington MK, Coffey RJ, Manning HC. Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. PLoS One. 2013; 8(3):e58938. PubMed PMID: 23554961; PubMed Central PMCID: PMC3598948.


McKinley ET, Liu H, McDonald WH, Luo W, Zhao P, Coffey RJ, Hanks SK, Manning HC. Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer. PLoS One. 2013; 8(11):e80207. PMCID: PMC3832668.


McKinley ET, Smith RA, Zhao P, Fu A, Saleh SA, Uddin MI, Washington MK, Coffey RJ, Manning HC. 3'-deoxy-3'-18f-fluorothymidine PET predicts response to v600eBRAF-targeted therapy in preclinical models of colorectal cancer. J Nucl Med, 2013; 54:424-30. PMCID: PMC3633462.


Saad R, Chen Z, Zhu S, Jia P, Zhao Z, Washington MK, Belkhiri A, El-Rifai W. Deciphering the unique microRNA signature in human esophageal adenocarcinoma. PLoS One, 2013; 8:e64463. PMCID: PMC3665888.


Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Jr., Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics, 2013; 8:1153-61. PMCID: PMC3927747.


Shelton EL, Galindo CL, Williams CH, Pfaltzgraff E, Hong CC, Bader DM. Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia. PLoS One, 2013; 8:e69712. PMCID: PMC3723636.


Tanksley JP, Chen X, Coffey RJ. Nedd4l is downregulated in colorectal cancer and inhibits canonical Wnt signaling. PLoS One, 2013; 8:e81514. PMCID: PMC3842946.


Thompson MM, Manning HC, Ellacott KL. Translocator protein 18 KDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One; 2013 (11):e79980. PMCID: PMC3832377.


Weis VG, Sousa JF, LaFleur BJ, Nam KT, Weis JA, Finke PE, Ameen NA, Fox JG, Goldenring JR. Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut, 2013; 62:1270-9. PMCID: PMC3762676.


Yachimski P, Shi C, Slaughter JC, Washington MK. Endoscopic mucosal resection of Barrett's esophagus detects high prevalence of subsquamous intestinal metaplasia. World J Gastrointest Endosc, 2013; 5:590-4. PMCID: PMC3870912.


Zaika E, Bhardwaj V, Wei J, Washington MK, Souza R, El-Rifai W, Zaika A. Proinflammatory cytokines and bile acids upregulate deltanp73 protein, an inhibitor of p53 and p73 tumor suppressors. PLoS One, 2013; 8:e64306. PMCID: PMC3661465.


Zhu S, Hong J, Tripathi MK, Sehdev V, Belkhiri A, El-Rifai W. Regulation of CXCR4-mediated invasion by Darpp-32 in gastric cancer cells. Mol Cancer Res, 2013; 11:86-94. PMCID: PMC3552044.


Bernard JK, McCann SP, Bhardwaj V, Washington MK, Frey MR. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. J Biol Chem, 2012; 287:39850-8. PMCID: 3501086.


Bhat AA, Sharma A, Pope J, Krishnan M, Washington MK, Singh AB, Dhawan P. Caudal homeobox protein cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. PLoS One, 2012; 7:e37174. PMCID: 3376107.


Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam D, Goldenring JR, Lacy DB. Clostridium difficile toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog, 2012; 8:e1003072. PMCID: 3516567.


Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Jr., Chaturvedi R, Zhao Z, Wilson KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One, 2012; 7:e33546. PMCID: 3299802.


Do N, Zhao R, Ray K, Ho K, Dib M, Ren X, Kuzontkoski P, Terwilliger E, Karp SJ. BMP4 is a novel paracrine inhibitor of liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2012;303(11):G1220-7. PMCID: PMC3532457.


Dube PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk DB. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest, 2012; 122:2780-92. PMCID: 3408743.


Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. Gastroenterology, 2012; 142:562-571 e2. PMCID: 3343368.


Hong J, Katsha A, Lu P, Shyr Y, Belkhiri A, El-Rifai W. Regulation of ErbB2 receptor by t-Darpp mediates trastuzumab resistance in human esophageal adenocarcinoma. Cancer Res, 2012; 72:4504-14. PMCID: 3432752.


Horvath DJ, Jr., Washington MK, Cope VA, Algood HM. IL-23 contributes to control of chronic Helicobacter pylori infection and the development of T helper responses in a mouse model. Front Immunol, 2012; 3:56. PMCID: 3342083.


Huderson AC, Myers JN, Niaz MS, Washington MK, Ramesh A. Chemoprevention of benzo(a)pyrene-induced colon polyps in Apc(min) mice by resveratrol. J Nutr Biochem., 2012; 24:713-24. PMCID: 3499643.


Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD. Neuron-specific deletion of peroxisome proliferator-activated receptor delta (ppardelta) in mice leads to increased susceptibility to diet-induced obesity. PLoS One, 2012; 7:e42981. PMCID: 3423438.


Leystra AA, Deming DA, Zahm CD, Farhoud M, Olson TJ, Hadac JN, Nettekoven LA, Albrecht DM, Clipson L, Sullivan R, Washington MK, Torrealba JR, Weichert JP, Halberg RB. Mice expressing activated PI3K rapidly develop advanced colon cancer. Cancer Res, 2012; 72:2931-6. PMCID: PMC3645915.


McKinley ET, Smith RA, Tanksley JP, Washington MK, Walker R, Coffey RJ, Manning HC. [18f]FLT-PET to predict pharmacodynamic and clinical response to cetuximab therapy in Menetrier's disease. Ann Nucl Med, 2012; 26:757-63. PMCID: 3543701.


Nam KT, O'Neal R, Lee YS, Lee YC, Coffey RJ, Goldenring JR. Gastric tumor development in smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. Lab Invest, 2012; 92:883-95. PMCID: 3584162.


Nam KT, O'Neal RL, Coffey RJ, Finke PE, Barker N, Goldenring JR. Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut. 2012; 61(12):1678-85. PMCID: PMC3767919.


O'Neal RL, Nam KT, Lafleur BJ, Barlow B, Nozaki K, Lee HJ, Kim WH, Yang HK, Shi C, Maitra A, Montgomery E, Washington MK, El Rifai W, Drapkin RI, Goldenring JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum Pathol, 2012; Oct 16. EPub ahead of print. PMCID: 3556378.


Oh SC, Park YY, Park ES, Lim JY, Kim SM, Kim SB, Kim J, Kim SC, Chu IS, Smith JJ, Beauchamp RD, Yeatman TJ, Kopetz S, Lee JS. Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut, 2012; 61:1291-8. PMCID: 3419333.


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McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk DB, Weitkamp JH. Transactivation of EGFR by LPS induces Cox-2 expression in enterocytes. PLoS One, 2012; 7:e38373. PMCID: 3364993.


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Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ. Amphiregulin exosomes increase cancer cell invasion. Curr Biol, 2011; 21:779-86. PMCID: 3417320.


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Albaugh VL, Flynn CR, Cai S, Xiao Y, Tamboli RA, Abumrad NN. Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1225-33. PubMed PMID:26196952; PubMed Central PMCID: PMC4570157.


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Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Williams SM, Signorello LB, Blot WJ, Matthews CE. Htr1b, adipor1, ppargc1a, and cyp19a1 and obesity in a cohort of Caucasians and African Americans: An evaluation of gene-environment interactions and candidate genes. Am J Epidemiol, 2012; 175:11-21. PMCID: 3244609.


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Gorrindo P, Williams KC, Lee EB, Walker LS, McGrew SG, Levitt P. Gastrointestinal dysfunction in autism: Parental report, clinical evaluation, and associated factors. Autism Res, 2012; 5:101-8. PMCID: 3335766.


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