Jeffrey Blume, PhD
Professor Blume is an Associate Professor in Biostatistics and Biomedical Inforamatics, in the School of Medicine, Vanderbilt University. He is the Director of Graduate Studies in the Department of Biostatistics and Co-Director of the Big Biomedical Data Science Ph.D. program. Professor Blume received his Ph.D. in Biostatistics from the John Hopkins School of Public Health, where he was the recipient of a National Eye Institute Traineeship in Clinical Trials. He has extensive experience in the development, operation, analysis, and methodological aspects of Clinical Trials. Before coming to Vanderbilt, he served as Deputy Director of the Biostatistics and Data Management Center for the American College of Radiology Imaging Network (ACRIN). ACRIN is a NCI funded cooperative group that specializes in clinical trials evaluating new medical imaging technology ( www.acrin.org).Professor Blume's research has been focused in three areas: (1) Likelihood methods for measuring statistical evidence / foundations of statistical inference, (2) methodology for analyzing and interpreting Receiver Operating Characteristic (ROC) curves, (3) the design, conduct and analysis of Clinical Trials. Professor Blume is working to bring likelihood methods to bear on statistical aspects of the drug/device approval process and to develop likelihood methods that will yield highly efficient adaptive clinical trial designs. Blume currently supervises numerous PhD candidates in his lab, who are working on an interesting variety of topics: missing data in prediction modeling, false discovery rates, mediation analyses, empirical Bayes methods, Prentice criterion for surrogate endpoints, and re-sampling methods.