Amritraj Patra

Amritraj Patra

Research Fellow

Amrit obtained his PhD degree in chemistry from Karlsruhe University in Germany. Nucleic acids with molecular caps as fidelity-enhancing elements for hybridization probes constituted a key aspect of his Ph.D. research. He used NMR to elucidate the three-dimensional structure of chemically modified DNA, which provided insight into the origins of the duplex-stabilizing effect of an anthraquinonyl residue attached to a DNA. During this time, He decided to gain experience in X-ray crystallography and structural biology. This led to pursue postdoctoral research with Prof. Martin Egli, at Vanderbilt University working on how cancer-causing chemicals interact with DNA to produce mutation. He used X-ray crystallography to delineate structural basis for lesion bypass by human polymerase enzyme.In 2016, Amrit joined Dr. Jens Meiler, Dr. Melanie Ohi and Dr. James Crowe at the center for structural biology and VVC. Using single particle cryo-EM and X-ray crystallography, he is currently conducting research to aid structure-based vaccine development against human norovirus and poxvirus.